Rh(Ⅲ)-Catalyzed Synthesis of Multisubstituted Isoquinoline and Pyridine N-Oxides from Oximes and Diazo Compounds

摘要

Multisubstituted isoquinoline and pyridine N-oxides have been prepared by Rh(Ⅲ)-catalyzed cycliz-ation of oximes and diazo compounds via aryl and vinylic G-H activation. This intermolecular annulation involving tandem C-H activation, cydization, and condensation steps proceeds under mild conditions, obviates the need for oxidants, releases N_2 and H_2O as the byproducts, and displays a broad substituent scope.