Retraction of 'Total Synthesis of Kaitocephalin, the First Naturally Occurring AMPA/KA Receptor Antagonist'

摘要

All of the authors retract this Communication after careful reinvestigation of the reported results. The final product of the last step was determined to be a mixture of 2-epi- and 9-epi-2-epi-kaitocephalins and other minor isomers, not the desired natural product. Natural kaitocephalin can be synthesized following the same synthetic protocol by using (S)-Garner aldehyde as the substrate in aldol reaction step and these results were described in a recent publication (see the following: Yu, S.; Zhu, S.; Pan, X.； Yang, J.； Ma, D. Tetrahedron 2011, 67, 1673-1680).