Palladium-catalyzed amination of aryl bromides: use of phosphinoether ligands for the efficient coupling of acyclic secondary amines

摘要

Recent developments in the palladium-catalyzed ami- nation of aryl halides offer considerable advantages over the classical methods, which require either activated substrates or sever reaction conditions. While these new methods, based on the use of the monophosphine ligand P(o-toolyl) or bis-phosphine ligands BINAP and DPPF, lead to efficient coupling of primary amines and Secondary cyclic amines, the arylation of secondary Acyclic amines remains problematic; the corresponding Tertiary aromatic amines are generally formed in low Yields.