Enzymatic Resolution of α-Alkyl β-Amino Acids Using Immobilized Penicillin G Acylase

摘要

We have demonstrated that immobilized penicillin G acylase is an effective reagent for the kinetic resolution of α-alkyl β-amino acids. The reaction time, the reaction temperature, the solvent, and the pH proved to be crucial for the yield and the enantiomeric purity of the products and should be attentively evaluated for each substrate.