Lewis Acid-Catalyzed Synthesis of Aziridines

摘要

We have shown that simple Lewis acids catalyze the reaction of EDA with imines to form a variety of aziridines. The mechanism for aziridine formation shown in Scheme 1 may also apply to some transition metal-catalyzed additions and must be considered when analyzing such results. We are currently investigating the use of chiral Lewis acids in these reactions.