A GENERAL SYNTHESIS OF PYRROLES AND FUSED PYRROLE SYSTEMS FROM KETONES AND AMINO ACIDS

摘要

The lithium enolates of ketones react with BOC-alpha-amino aldehydes and BOC-alpha-amino ketones to afford aldol intermediates that cyclize under acidic conditions to yield pyrroles. The BOC-amino aldehydes and ketones are readily available from ol-amino acids. The method allows incorporation of a wide variety of substituents at any of the five atoms of the pyrrole ring and is also suitable for the preparation of fused pyrrole systems. [References: 15]