Stereoselective Synthesis of (+)-Goniothalesdiol

摘要

Stereoselective synthesis of antitumor tetrahydrofuran (+)-goniothalesdiol was achieved in high overall yield from (-)-D-tartaric acid.Key features include an FeCl_3 mediated THF formation with very high selectivity.Synthesis of natural gonithalesdiol and its analogue 2,5-bis-epi-goniotha-lesdiol was achieved from a common intermediate.