Novel Synthons from Mucochloric Acid: The First Use of α,β-Dichloro-γ-butenolides and γ-Butyrolactams for Direct Vinylogous Aldol Addition

摘要

Novel 5-(1′-hydroxy)-γ-butyrolactone and γ-butyrolactam subunits were synthesized by direct vinylogous aldol addition of α,β-dichloro γ-butyrolactones and γ-butyrolactams with aldehydes under basic conditions. Different bases and solvents were screened in the context of generating γ-butyrolactones. Diastereo-selectivity was observed and γ-butenolides and γ-butyrolactams showed opposite diastereoselectivity under the same reaction condition.