Outstanding Scientists In The World Of Organ Dysfunction

摘要

In the etiology of multiple organ dysfunction syndrome (MODS), sepsis has been considered to be representative of bacteria- and bacterial toxin-associated organ inflammation and dysfunction, while acute pancreatitis (AP) is a non-septic representative of diseases leading to the development of MODS. Dr Roland Andersson is one of a few leading scientists exploring the mechanisms of both septic and non-septic MODS, investigating the similarities between and variation in MODS induced by abdominal sepsis and AP and identifying potential inter-organ signaling mechanisms. His scientific focus has changed from single-organ damage (gut ischemia) to multiple organ dysfunction (hepato-pancreato-biliary diseases, abdominal sepsis and various inflammatory conditions), and from a single system (reticuloendothelial function) to multiple systems (leukocyte system activation, endothelial barrier dysfunction and epithelial system compromise). One of his early contributions was to understand alterations in reticuloendothelial function in multiple diseases and organs. Dr Andersson was one of the very first to provide both clinical and experimental evidence to show the migration of bacteria from the intestinal lumen to the systemic circulation and other organs in liver injury induced by major liver resection or chemicals. In addition, he was one of the first and one of the most active scientists to suggest that bacterial translocation occurs in sple-nectomy, intraperitoneal implantation, obstructive jaundice, gut ischemia and reperfusion, and AP. Dr Andersson should be greatly appreciated for his efforts to understand cellular and molecular mechanisms of AP-associated MODS, comparison of the differentiation of MODS induced by sepsis and pancreatitis, mechanisms underpinning the development of MODS and potential therapies for its prevention and treatment.