Investigation on Risk Factors of Cerebrocardiac Vascular Thrombotic Diseases in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

摘要

Objective:To observe the risk factors of thrombosis in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods: From February 2001 to April 2003, 24 patients with moderate and severe OSAHS (OSAHS group) and 19 healthy adults (control group) were recruited. Their blood samples were drawn at 6:00 and 16:00 respectively for testing hem-ocrit, platelet aggregation (PAG), whole blood viscosity (WBV), prothrombin time (PT), activated partial thromboplastin time (APTT), plasmafibrinogen (Fng) and endothelin (ET). Results: There was a significantly higher hemocrit, WBV, Fng and ET as well as a significant shortening of PT and APTT at 6:00 than that at 16:00 in OSAHS group. However, there was no significant difference in all testing items between 6:00 and 16:00 in control group. The hemocrit, WBV, PAG, plasma Fng and ET were significantly higher, and PT and APTT were obviously shorter at 6:00 in OSAHS group than those at 6:00 in control group. A higher hemocrit, PAG, plasma Fng and ET, a longer PT and APTT were observed at 16:00 in OSAHS group, compared with those at 16:00 in control group. Conclusion: In OSAHS patients there were striking risk factors of thrombosis, which is more remarkable in the early morning than in the afternoon.