Strong Anti-Platelet Aggregation and Plasma Fibrinolysis-Accelerating Activities in Oyster Fungus (Pleurotus ostreatus)

摘要

The substances for inhibiting blood platelet aggregation were screened in the water-soluble fraction of mushrooms cultivated on a sawdust base. Oyster fungus (Pleurotus ostreatus) was especially strong in blocking the aggregation of human platelets (220 × 10~6/ml) caused by ADP, collagen or thrombin, the IC_50 being calculated as about 11.6 -27.1μg/ml in dry weight. It was a dark yellow solution and maintained more than 90 of its anti-platelet aggregation activity after boiling at 100℃ for 1 h. The active substances that were extracted and freeze-dried from oyster fungus inhibited platelet aggregation in both rats (i.p.) and humans (oral). The acceleration of plasma fibrinolysis due to the release of tissue plasminogen activator (t-PA) was also confirmed in humans. Since this substance was heat-resistant and can be mass-produced, it is expected that the material can be developed and practically applied as a functional food for preventing several thrombotic diseases.