INTERPRETIVE SUMMARIES, MAY 2014

摘要

Effect of cell-surface components and metabolites of lactic acid bacteria and probiotic organisms on cytokine production and induction of CD25 expression in human peripheral mononuclear cells. By Ashraf et al., page 2542. The immunomod-ulatory role of cell-surface components and metabolites of 17 strains of probiotic and lactic acid bacteria were compared. Prom the different immune factors tested, proinflammatory immune responses were mainly directed through cell-surface structures but antiinflammatory immune responses were mediated by both metabolites and cell-surface structures of these bacteria. Moreover, regulatory T-cell activity was principally triggered by cell-surface structures, indicating that bacterial components differed in their immune effects. Bacterial strains demonstrating high induction of regulatory T-cell count could be helpful in maintaining self-tolerance and in the treatment of autoimmune diseases.