Synthesis, Antibacterial and Antitumor Activity of 3-Me-thyl-7-oxo-9-fluoro-10-alkyloxy (or Arayloxy)-2,3-dihydro-7Hpyrido[1,2,3-del][1,4] benzoxazine-6-carboxylic Acids and Analogues

摘要

Some 3-methly-7-oxo-9-fluoro-10-alkyloxy (or aryloxy)-2,3-dihydro-7H-pyrido [1,2,3-de][1,4]benzoxazine-6-carboxylic acids and analogues were synthesized. The in vitro antibacterial tests showed that the effect of the 10-alkyloxy compounds (especially the fluoroethyloxy compound 3d) was much better than that of the 10-hydroxy compound 3a. The antitumor test showed that some target compounds possessed moderate or low cytotoxicity against LAX and P388 in the culture.