Palladium-Catalyzed Functionalization of Lactones via Their Cyclic Ketene Acetal Phosphates. Efficient New Synthetic Technology for the Construction of Medium and Large Cyclic Ethers

摘要

The chemistry described above demonstrates the usefulness of cyclic ketene acetal phosphates as stable and easily accessible substrates for palladium-catalyzed coupling reaction. Their superiority over cyclic ketene acetal triflates in terms of cost and availability of reagents for their synthesis, stability, and efficiency of formation and coupling should make them the substrates of choice for such operation. Other reactions and applications of ketene acetal phosphates are currently under investigation.