Radical Carboxylation: Ester Synthesis from Alkyl Iodides, Carbon Monoxide, and Alcohols under Irradiation Conditions

摘要

Thus, we have shown that an efficient conversion of aliphatic iodides to the corresponding esters is possible by simply using irradiation in the visible region without the use of a metal catalyst. A free radical mechanism for this reaction is highly likely, but gratifyingly, the process requires neither radical mediator nor photosensitizer. Importantly, the basic principle of photoinduced catalyst-free carboxylation demonstrated here may have promise in terms for a wide range of other carbonyl compounds.