Novel phosphitylating reagents containing a phosphorus–fluorine bond and their application in efficient synthesis of phosphorofluoridates and phosphorofluoridothionates

摘要

Novel phosphitylating reagents containing a P–F bond are obtained in excellent yield from commercial materials.nThey react with alcohols at 20 u0001C in neutral solvents in the presence of tetrazole, chlorotrimethylsilane or benzoylnchloride to give the intermediate phosphorofluoridites. Subsequent oxidation or sulfurization followed by thenremoval of protecting groups gives the phosphorofluoridates and thiophosphorofluoridates in over 90% total yield.