Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer

Hiroji Uemura; Hisashi Hasumi; Takashi Kawahara; Shinpei Sugiura; Yasuhide Miyoshi; Noboru Nakaigawa; Jun-ichi Teranishi; Kazumi Noguchi; Hitoshi Ishiguro; Yoshinobu Kubota

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Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer

机译：血管紧张素Ⅱ受体阻滞剂治疗晚期激素难治性前列腺癌的初步研究

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We previously demonstrated that an angiotensin II receptor blocker (ARB) had the potential to inhibit cell proliferation of prostate cancer. In this study, we examined whether an ARB could elicit an antiproliferative effect on hormone-refractory prostate cancer, clinically.

机译：我们先前证明了血管紧张素II受体阻滞剂（ARB）具有抑制前列腺癌细胞增殖的潜力。在这项研究中，我们研究了ARB是否可以在临床上对激素难治性前列腺癌引起抗增殖作用。

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来源
《International Journal of Clinical Oncology》 |2005年第6期|405-410|共6页
作者
Hiroji Uemura; Hisashi Hasumi; Takashi Kawahara; Shinpei Sugiura; Yasuhide Miyoshi; Noboru Nakaigawa; Jun-ichi Teranishi; Kazumi Noguchi; Hitoshi Ishiguro; Yoshinobu Kubota;
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作者单位

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Medical Center Yokohama Japan;

Department of Urology Yokohama City University Medical Center Yokohama Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

Department of Urology Yokohama City University Graduate School of Medicine 3-9 Fukuura Kanazawa-ku Yokoyama 236-0004 Japan;

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正文语种 eng
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关键词
Angiotensin II receptor blocker; Hormone-refractory prostate cancer; Prostate-specific antigen;

机译：血管紧张素Ⅱ受体阻滞剂;激素难治性前列腺癌;前列腺特异性抗原;抗肿瘤药;

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专利

1. Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer. [J] . Uemura H, Hasumi H, Kawahara T, International journal of clinical oncology . 2005,第6期

机译：血管紧张素II受体阻滞剂在晚期激素难治性前列腺癌中的初步研究。
2. Ets-1 and hypoxia inducible factor-1alpha inhibition by angiotensin II type-1 receptor blockade in hormone-refractory prostate cancer. [J] . Kosaka T, Miyajima A, Shirotake S, The Prostate . 2010,第2期

机译：在激素难治性前列腺癌中，血管紧张素II 1型受体阻滞抑制Ets-1和缺氧诱导因子1α。
3. Impact of angiotensin I converting enzyme inhibitors and angiotensin II type 1 receptor blockers on survival in patients with advanced non-small-cell lung cancer undergoing first-line platinum-based chemotherapy. [J] . Wilop S, von Hobe S, Crysandt M, Journal of Cancer Research and Clinical Oncology . 2009,第10期

机译：血管紧张素I转化酶抑制剂和血管紧张素II 1型受体阻滞剂对接受一线铂类化疗的晚期非小细胞肺癌患者生存的影响。
4. A Pilot Study on Understanding the Journey of Advanced Prostate Cancer Patients [C] . Amol WAGHOLIKAR, Maggie FUNG Colleen NELSON Australian National Health Informatics Conference . 2011

机译：了解高级前列腺癌患者之旅的试验研究
5. Therapeutic Targeting of Stat5a/b in Advanced Prostate Cancer: Inhibition of Stat5a/b Suppresses Growth of Prostate Cancer through Mechanisms Dependent and Independent of Androgen Receptor. [D] . Hoang, David Timothy. 2016

机译：Stat5a / b在晚期前列腺癌中的治疗靶点：Stat5a / b的抑制作用通过依赖于雄激素受体的机制来抑制前列腺癌的生长。
6. A phase II study of afatinib an irreversible ErbB family blocker added to letrozole in patients with estrogen receptor-positive hormone-refractory metastatic breast cancer progressing on letrozole [O] . Katharina Gunzer, Florence Joly, Jean-Marc Ferrero, -1

机译：afatinib是一种不可逆的ErbB家族阻滞剂的II期研究已在来曲唑治疗的雌激素受体阳性激素难治性转移性乳腺癌患者中加入来曲唑
7. Use of β-Blockers, Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Risk of Breast Cancer Recurrence:A Danish Nationwide Prospective Cohort Study [O] . Sørensen, Gitte Vrelits, Ganz, Patricia A, Cole, Steven W, 2013

机译：使用β受体阻滞剂，血管紧张素转换酶抑制剂，血管紧张素II受体阻滞剂和乳腺癌复发风险：丹麦全国前瞻性队列研究

Pilot study of angiotensin II receptor blocker in advanced hormone-refractory prostate cancer

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