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首页> 外文期刊>Helvetica Chimica Acta >Cytotoxic Evaluation of Pungencine: A New Tropane Alkaloid from the Roots of Erythroxylum pungens O. E. Schulz
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Cytotoxic Evaluation of Pungencine: A New Tropane Alkaloid from the Roots of Erythroxylum pungens O. E. Schulz

机译：刺桐的细胞毒性评价：刺桐根中的一种新的托罗宾生物碱。

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摘要

A new tropane alkaloid as well as a new substitution group, (3-endo,8-anti)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 4-hydroxy-3,5-dimethoxybenzoate, called pungencine (1), was isolated from the roots of Erythroxylum pungens O. E. Schulz. The structure was elucidated by spectral analyses, including 1H- and 13C-NMR and 2D-NMR techniques (1H,1H-COSY, NOESY, DEPT, HMQC, and HMBC) and HR-ESI-MS. Furthermore, compound 1 was tested for cytotoxicity against several cell lines (Jurkat, HL-60, U937, K562, KG-1, and U266) and was determined not to inhibit cell viability at 10 μM.
机译：一种新的托烷生物碱以及一个新的取代基，称为（3-endo，8-anti）-8-methyl-8-azabicyclo [3.2.1] oct-3-yl 4-hydroxy-3,5-dimethoxybenzoate从刺桐（Erythroxylum pungens O. E. Schulz）的根中分离出pungencine（1）。通过光谱分析阐明了该结构，包括 1 H-和 13 C-NMR和2D-NMR技术（ 1 H， 1 H-COSY，NOESY，DEPT，HMQC和HMBC）和HR-ESI-MS。此外，测试了化合物1对几种细胞系（Jurkat，HL-60，U937，K562，KG-1和U266）的细胞毒性，并确定在10μm时不抑制细胞活力。

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  • 来源
    《Helvetica Chimica Acta》 |2010年第9期|p.1742-1744|共3页
  • 作者

    José G. Sena-Filho; Marcelo S. da Silva; Josean F. Tavares; Steno L. Oliveira; Marco A. V. Romero; Haroudo S. Xavier; Jose M. Barbosa-Filho; Raimundo Braz-Filho;

  • 作者单位

    Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, Caixa Postal 5009, 58051-970, João Pessoa, PB, Brazil (phone: +55-79-4009-1387/+55-79-9116-9472;

    fax: +55-83-3216-7502)|Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA, Coastal Tablelands, Av. Beira mar, 3250, 49025-040, Aracaju, SE, Brazil;

    Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, Caixa Postal 5009, 58051-970, João Pessoa, PB, Brazil (phone: +55-79-4009-1387/+55-79-9116-9472;

    fax: +55-83-3216-7502);

    Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, Caixa Postal 5009, 58051-970, João Pessoa, PB, Brazil (phone: +55-79-4009-1387/+55-79-9116-9472;

    fax: +55-83-3216-7502);

    Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, Caixa Postal 5009, 58051-970, João Pessoa, PB, Brazil (phone: +55-79-4009-1387/+55-79-9116-9472;

    fax: +55-83-3216-7502);

    Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, Caixa Postal 5009, 58051-970, João Pessoa, PB, Brazil (phone: +55-79-4009-1387/+55-79-9116-9472;

    fax: +55-83-3216-7502);

    Universidade Federal de Pernambuco-Laboratório de Farmacognosia Cidade Universitária, 50740-521, Recife, PE, Brazil;

    Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, Caixa Postal 5009, 58051-970, João Pessoa, PB, Brazil (phone: +55-79-4009-1387/+55-79-9116-9472;

    fax: +55-83-3216-7502);

    Pesquisador Visitante Emérito – FAPERJ/UENF/UFRRJ, 28013-602 Campos, RJ, Brazil;

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  • 正文语种 eng
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  • 关键词

    Erythroxylum pungens; Tropane alkaloids; Pungencine; Cytotoxic activity; Alkaloids;

    机译：丹参;戊烷生物碱;刺槐碱;细胞毒活性;生物碱;

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