An association between arterial pulse pressure and variation in the fibrillin-1 gene

摘要

Conclusions-There appears to be a sig- nificant association between fibrillin-1 genotype and arterial pulse pressure in men aged 50 to 61 years. Objective-To investigate whether varia- Tion in the fibrillin-1 gene was associated With blood pressure in healthy middle Aged men, as had been observed in Patients with abdominal aortic aneurysm. Design, setting, and patients-Middle Aged men (n = 245), aged 50 to 61 years, Were recruited from one of the nine General practices participating in the sec- Ond Northwick Park heart study. Blood Samples were obtained for the preparation Of genomic DNA and analysis of plasma Variables.