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首页> 外文期刊>Genetic Testing >Lack of Association Between Polymorphism -592A/C in the Promoter Region of the IL10 Gene and Tourette's Syndrome in a Family-Based Association Study in the Chinese Han Population
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Lack of Association Between Polymorphism -592A/C in the Promoter Region of the IL10 Gene and Tourette's Syndrome in a Family-Based Association Study in the Chinese Han Population

机译：在基于汉族的中国汉族人群中，IL10基因启动子区多态性-592A / C与图雷特氏综合症之间缺乏关联

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摘要

We evaluated the genetic contribution of the IL10-592A/C polymorphism in 108 trios with Tourette's syndrome (TS) including all their parents in a Chinese Han population by using the transmission disequilibrium test and haplotype relative risk design; no evidence for association or linkage disequilibrium was found between IL10-592A/C polymorphism and TS. These results suggested that IL10 may not play a major role in the development of TS in the Chinese Han population.
机译：我们使用传播不平衡检验和单倍型相对风险设计，评估了108例图雷特氏综合症（TS）三重症患者的IL10-592A / C基因多态性的遗传贡献，其中包括他们的所有父母。没有发现IL10-592A / C多态性与TS之间存在缔合或连锁不平衡的证据。这些结果表明，IL10可能在中国汉族人群TS的发展中不发挥主要作用。

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  • 来源
    《Genetic Testing》 |2011年第10期|p.733-735|共3页
  • 作者

    Shiguo Liu; Mingji Yi; Fengguang Qi; Fengyuan Che; Xu Ma;

  • 作者单位

    Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China,Institute of Clinical Research, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China,Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China;

    Child Healthcare Department, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China;

    Medical School, Qingdao University, Qingdao, China;

    Neurology Department, The Affiliated Linyi People's Hospital, Shandong University, Linyi, China,Neurology Department The Affiliated Linyi People's Hospital Shandong University Shandong Provence 27 Jiefang Road Linyi 276000 China;

    Graduate School, Peking Union Medical College, Beijing, China,Center for Genetics, National Research Institute for Family Planning, Beijing, China,World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China,Center for Genetics National Research Institute for Family Planning 12, Dahuisi Road Haidian Beijing 100081 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
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