Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

Aiman Abrahim; Gert Luurtsema; Martin Bauer; Rudolf Karch; Mark Lubberink; Ekaterina Pataraia; Christian Joukhadar; Kurt Kletter; Adriaan A. Lammertsma; Christoph Baumgartner; Markus Müller; Oliver Langer

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Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

机译：（R）-[11 C]维拉帕米在癫痫患者中的外周代谢

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摘要

(R)-[11C]verapamil is a new PET tracer for P-glycoprotein-mediated transport at the blood-brain barrier. For kinetic analysis of (R)-[11C]verapamil PET data the measurement of a metabolite-corrected arterial input function is required. The aim of this study was to assess peripheral (R)-[11C]verapamil metabolism in patients with temporal lobe epilepsy and compare these data with previously reported data from healthy volunteers.

机译：（R）-[11 C]维拉帕米是一种新的PET示踪剂，用于P-糖蛋白介导的血脑屏障转运。为了对（R）-[11 C]维拉帕米PET数据进行动力学分析，需要测量代谢物校正的动脉输入功能。这项研究的目的是评估颞叶癫痫患者外周血（R）-[11 C]维拉帕米的代谢，并将这些数据与健康志愿者先前报道的数据进行比较。

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来源
《European Journal of Nuclear Medicine and Molecular Imaging》 |2008年第1期|116-123|共8页
作者
Aiman Abrahim; Gert Luurtsema; Martin Bauer; Rudolf Karch; Mark Lubberink; Ekaterina Pataraia; Christian Joukhadar; Kurt Kletter; Adriaan A. Lammertsma; Christoph Baumgartner; Markus Müller; Oliver Langer;
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作者单位

Department of Clinical Pharmacology Division of Clinical Pharmacokinetics Medical University of Vienna Währinger-Gürtel 18–20 1090 Vienna Austria;

Department of Nuclear Medicine ampamp PET Research VU University Medical Centre Amsterdam The Netherlands;

Department of Clinical Pharmacology Division of Clinical Pharmacokinetics Medical University of Vienna Währinger-Gürtel 18–20 1090 Vienna Austria;

Department of Medical Computer Sciences Medical University of Vienna Vienna Austria;

Department of Nuclear Medicine ampamp PET Research VU University Medical Centre Amsterdam The Netherlands;

Department of Neurology Medical University of Vienna Vienna Austria;

Department of Clinical Pharmacology Division of Clinical Pharmacokinetics Medical University of Vienna Währinger-Gürtel 18–20 1090 Vienna Austria;

Department of Nuclear Medicine Medical University of Vienna Vienna Austria;

Department of Nuclear Medicine ampamp PET Research VU University Medical Centre Amsterdam The Netherlands;

Department of Neurology Medical University of Vienna Vienna Austria;

Department of Clinical Pharmacology Division of Clinical Pharmacokinetics Medical University of Vienna Währinger-Gürtel 18–20 1090 Vienna Austria;

Department of Clinical Pharmacology Division of Clinical Pharmacokinetics Medical University of Vienna Währinger-Gürtel 18–20 1090 Vienna Austria;

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正文语种 eng
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关键词
(R)-11Cverapamil; Metabolism; Antiepileptic drugs; P-glycoprotein; Cytochrome P450; Enzyme induction; PET;

机译：（R）-[11C]维拉帕米;代谢;抗癫痫药;P-糖蛋白;细胞色素P450;酶诱导;PET;

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专利

1. Peripheral metabolism of (R)-((11)C)verapamil in epilepsy patients. [J] . Abrahim A, Luurtsema G, Bauer M, European Journal of Nuclear Medicine and Molecular Imaging . 2008,第1期

机译：癫痫患者的（R）-（（11）C）维拉帕米的外周代谢。
2. P-glycoprotein imaging in temporal lobe epilepsy: in vivo PET experiments with the Pgp substrate [11C]-verapamil. [J] . Maria Feldmann, Matthias Koepp Epilepsia: Journal of the International League against Epilepsy . 2012,第Suppla6期

机译：颞叶癫痫中的P-糖蛋白成像：使用Pgp底物[11C]-维拉帕米的体内PET实验。
3. P-glycoprotein imaging in temporal lobe epilepsy: in vivo PET experiments with the Pgp substrate [11C]-verapamil. [J] . Maria Feldmann, Matthias Koepp Epilepsia: Journal of the International League against Epilepsy . 2012,第Suppla6期

机译：颞叶癫痫中的p-糖蛋白成像：在具有PGP底物的体内PET实验[11c] - 使帕米尔。
4. Kinetics of (R)-11C rolipram and (S)-11C rolipram In the Dog Heart: Investigation of Four Compartment Models [C] . Lortie, M., DaSilva, . 2006

机译：（R）-11C咯利普兰和（S）-11C咯利普兰在犬心中的动力学：四种室模型的研究
5. Stereoselective metabolism of verapamil and four other chiral drugs by cDNA expressed CYP450's. [D] . Shen, Lixin. 2003

机译：维拉帕米和其他四种手性药物通过cDNA的立体选择性代谢表达CYP450。
6. Effects of verapamil on haemodynamic function and myocardial metabolism in patients with hypertrophic cardiomyopathy. [O] . P T Wilmshurst, D S Thompson, S M Juul, 1986

机译：维拉帕米对肥厚型心肌病患者血流动力学功能和心肌代谢的影响。
7. Metabolism of (R)-[¹¹C]verapamil in epilepsy patients [O] . Kletter Kurt, Baumgartner Christoph, Karch Rudolf, 2007

机译：[ R ）-[^{11 C]维拉帕米在癫痫患者中的代谢}

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients

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