Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial

Michał Tendera1* Wojciech Wojakowski1 Witold Rużyłło2 Lidia Chojnowska2 Cezary Kępka2 Wiesława Tracz3 Piotr Musiałek3 Wiesława Piwowarska4 Jadwiga Nessler4 Paweł Buszman1 Stefan Grajek5 Piotr Bręborowicz5 Marcin Majka6 and Mariusz Z. Ratajczak7 for the REGENT Investigators (REGENT investigators are listed in the Appendix)

首页> 外文期刊>European Heart Journal >Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial

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Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial

机译：急性STEMI和左心室射血分数降低的患者的骨髓源选择的CD34 + CXCR4 + 细胞和未选择的单核细胞的冠状动脉内输注：随机，多中心结果在急性心肌梗死（REGENT）试验中，通过冠状动脉内输注选定的干细胞群体来再生心肌

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Aims Comparison of intracoronary infusion of bone marrow (BM)-derived unselected mononuclear cells (UNSEL) and selected CD34+CXCR4+ cells (SEL) in patients with acute myocardial infarction (AMI) and reduced 40% left ventricular ejection fraction (LVEF).

机译：目的比较急性心肌梗死患者骨髓（BM）来源的非选择单核细胞（UNSEL）和选择的CD34 + CXCR4 + 细胞（SEL）的冠状动脉内输注（ AMI），左心室射血分数（LVEF）降低了<40％。

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《European Heart Journal》 |2009年第11期|p.1313-1321|共9页
作者
Michał Tendera1* Wojciech Wojakowski1 Witold Rużyłło2 Lidia Chojnowska2 Cezary Kępka2 Wiesława Tracz3 Piotr Musiałek3 Wiesława Piwowarska4 Jadwiga Nessler4 Paweł Buszman1 Stefan Grajek5 Piotr Bręborowicz5 Marcin Majka6 and Mariusz Z. Ratajczak7 for the REGENT Investigators (REGENT investigators are listed in the Appendix);
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1Third Division of Cardiology, Medical University of Silesia, 45-47 Ziołowa Street, 40-635 Katowice, Poland 2First Department of Coronary Artery Disease and Catheterization Laboratory, Institute of Cardiology, Warsaw, Poland 3Department of Cardiac and Vascular Diseases, Jagiellonian University, Kraków, Poland 4Department of Coronary Disease, Jagiellonian University, Kraków, Poland 5First Department of Cardiology, Poznań University of Medical Sciences, Poznań, Poland 6Department of Transplantology, Polish-American Children's Hospital, Medical College, Jagiellonian University, Kraków, Poland 7Stem Cell Institute, University of Louisville, Louisville, KY, USA;

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1. Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by Intracoronary Infusion of Selected Population of Stem Cells in Acute Myocardial Infarction (REGENT) Trial. [J] . Tendera M, Wojakowski W, Ruzyllo W, European Heart Journal: The Journal of the European Society of Cardiology . 2009,第11期

机译：急性STEMI和左心室射血分数降低的患者中骨髓来源的选定CD34 + CXCR4 +细胞和未选定的单核细胞的冠状动脉内输注：通过急性心肌梗死中特定干细胞群体的冠状动脉内输注对随机，多中心心肌再生的结果（REGENT）试用。
2. Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial. [J] . Schachinger V, Assmus B, Erbs S, European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2009,第10期

机译：骨髓源性单核细胞的冠状动脉内灌注消除了急性心肌梗死后不利的左心室重构：在急性心肌梗死（REPAIR-AMI）试验中，从富集祖细胞的重新灌注和梗死重塑中获得的见解。
3. Intracoronary infusion of bone marrow-derived mononuclear cells abrogates adverse left ventricular remodelling post-acute myocardial infarction: insights from the reinfusion of enriched progenitor cells and infarct remodelling in acute myocardial infarction (REPAIR-AMI) trial [J] . Volker Schächinger1*†‡ Birgit Assmus1‡ Sandra Erbs2 Albrecht Elsässer3 Werner Haberbosch4 Rainer Hambrecht5 Jiangtao Yu6 Roberto Corti7 Detlef G. Mathey8 Christian W. Hamm9 Torsten Tonn10 Stefanie Dimmeler1 and Andreas M. Zeiher1 for the REPAIR-AMI investigators European Journal of Heart Failure . 2009,第10期

机译：骨髓源性单个核细胞的冠状动脉内灌注消除了急性心肌梗死后不良的左心室重构：急性心肌梗死（REPAIR-AMI）试验中富集祖细胞的再灌注和梗死重构的见解
4. Intracoronary infusion of autologous CD133~+ cells in myocardial infarction and tracing by Tc-99m MIBI scintigraphy of the heart areas involved in cell homing [C] . Kurbonov U., Dustov A., Barotov A., World Congress on Heart Disease. . 2013

机译：在细胞归巢中涉及Cell归巢的心脏区域的心肌梗死中自体梗死中的自体CD133〜+细胞的Intoracoronary indusion
5. Evaluation of bone marrow derived stem cells in the treatment of acute myocardial infarction [D] . Davy, Philip M. C. 2011

机译：骨髓源性干细胞治疗急性心肌梗死的评估
6. Effect of Intracoronary Delivery of Autolologous Bone Marrow Mononuclear Cells Two to Three Weeks Following Acute Myocardial Infarction on Left-Ventricular Function: The LateTIME Randomized Trial [O] . Dr Jay H. Traverse, Dr Timothy D. Henry, Dr Stephen G. Ellis, -1

机译：急性心肌梗死术后急性心肌梗死术后两至三周的颈内骨髓骨髓性梗死术后两至三周的疗效：拉短时期随机试验
7. TCTAP A-154 Intracoronary Infusion of Bone Marrow-derived Selected CD34+CXCR4+ Cells and Non-selected Mononuclear Cells in Patients with Acute STEMI and Reduced Left Ventricular Ejection Fraction. Extended 6-year Follow-up of Randomized, Multicenter REGENT Trial [O] . Wojakowski Wojciech 2014

机译：患有急性STEMI和左心室射血分数减少的患者的TCTAP A-154冠状动脉内输注骨髓来源的选定CD34 + CXCR4 +细胞和未选定的单核细胞。随机多中心REGENT试验的6年扩展随访

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