Identification of Somatotrophs, Mammosomatotrophs, and Mammotrophs by Sandwich Cell Immunoblot Assay in GH- Secreting Adenomas and Prolactinomas: Correlations Between the Proportions of Hormone Secreting Cells and Tumor Size

摘要

Sandwich cell immunoblot assay(sandwich CIBA) was used to dientify somatotrophs (GH cells), mam- mosomatotrophs, and mammotrophs (PRL cells) in pituitary tumors obtained from patients with GH-secreting adenomas and prolactinomas. The mean serum GH level was 177.6 ng/ml in 19 patients with GH-secreting ade- nomas and the mean PRL level was 2, 129 ng/ml in 9 patients with prolactinomas. GH-secreting adenomas could be divided into 3 groups according to the proportions of the cell types.