Physiological Roles Of Corticotropin-Releasing Hormone Receptor Type 2

摘要

Recent investigations of the physiological roles of CRH-R2 are reviewed and summarized in Fig. 5. VMH CRH-R2 is more important than CRH-R1 in mediating anorexic effect of CRH or urocortin (UCN) and stress-induced reduction of food intake. CRH-R2 mediates a central anxiolytic response, op- posing the anxiogenic effect of CRH mediated by CRH-R1. Hippocampal CRH-R1 mediates stress- induced enhancement of learning, while CRH-R2 in the lateral intermediate septum may act to impair learning. CRH-R1 mediates CRH-induced blood pressure elevation, while peripheral CRH-R2 medi- ates the hypotensive effect of systemically admin- istered UCN and CRH.