Interogran Signaling Between Adipose Tissue Metabolism and Skeletal Muscle Uncoupling Protein Homologs: Is There a Role for Circulating Free Fatty Acids?

摘要

Uncoupling proteins 3 and 2 (UCP3 and UCP2) are two newly cloned genes that have been implicated in the reg- ulation of lipids as fuel substrate in skeletal muscle on the basis that their mRNA expressions are upregulated during starvation (when fat stores are being rapidly mobilized) and downregulated during the early phase of refeeding (when fat stores are being rapidly replen- ished). To test the hypothesis that circulating free fatty acids (FFAs) may have a physiological role as an interorgan signal linking these dynamic changes in the fat stores to skeletal muscle expression of UCP3 and UCP2, the mRNA levels of these UCP homologs were Examined in fed and fasted rats treated with the Antilipolytic agent nicotinic acid.