Genes Expressed During the Differentiation of Pancreatic AR42J Cells Into Insulin-Secreting Cells

摘要

Pancreatic AR42J cells have the feature of pluripo- tency of the common precursor cells of the pancreas. Dexamethasone (Dx) converts them to exocrine cells, Whereas activin A (Act) converts them to exocrine cells, Cells expressing pancreatic polypeptide. A combination Of Act and betacellulin (BTC0 converts them further Into insulin-secreting cells. The present study identifies Some of the genes involved in the process of differen- Tiation that is induced by these factors, using the mRNA differential display and screening of the cDNA Expression array.