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SIRT1 mRNA Expression May Be Associated With Energy Expenditure and Insulin Sensitivity

机译：SIRT1 mRNA表达可能与能量消耗和胰岛素敏感性相关

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摘要

Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is associated with energy expenditure and insulin sensitivity.
机译：Sirtuin 1（SIRT1）与啮齿类动物的线粒体功能，能量代谢和胰岛素敏感性有关。在人类中尚无研究证明胰岛素敏感组织中SIRT1的表达与能量消耗和胰岛素敏感性有关。

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  • 来源
    《Diabetes》 |2010年第4期|p.829-835|共7页
  • 作者

    Jarno Rutanen Nagendra Yaluri Shalem Modi Jussi Pihlajamäki Markku Vänttinen Paula Itkonen Sakari Kainulainen Hiroyasu Yamamoto Marie Lagouge David A Sinclair Peter Elliott Christoph Westphal Johan Auwerx Markku Laakso;

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    Jarno Kutanen,1 Nagendra Yaluri,1 Shale m Modi,1 Jussi Pihlajamäki,1 Markku Vänttinen,1 Paula Itkonen,1 Sakari Kainulainen,2 Hiroyasu Yamamoto,3,4 Marie Lagouge,3 David A. Sinclair,5 Peter Elliott,6 Christoph Westphal,6 Johan Auwerx,3,4 and Markku Laakso1From the 1 Department of Medicine. University of Kuopio and Kuopio University Hospital, Kuopio. Finland, the 'Department of Clinical Radiology, University of Kuopio, Kuopio, Finland, the ^'Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur, Wkirch. France, the ^Laboratory of Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, the '^Department of Pathology and Glenn Labs for Aging Research, Harvard Medical School, Boston, Massachusetts, and 6Sirtris Pharmaceuticals, Cambridge, Massachusetts.Corresponding author: Markku Laakso, markku.laakso@kuh.fLReceived Il August 2009 and accepted 20 January 2010. Published ahead of print at http://diabetes.diabetesjournals.org on 27 January 2010. DOI: 10.2337/db09-U91.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/liccnses/by -nc-nd/3.0/ for details.Tlie costs of publication of litis article were defrayed in part by the payment of page charges. This article must therefoiv be hereby marked "advertisement" in accorxlance with 18 U.S.C. Section 1734 saely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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