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The T-Allele of TCF7L2 rs7903146 Associates With a Reduced Compensation of Insulin Secretion for Insulin Resistance Induced by 9 Days of Bed Rest

机译:TCF7L2 rs7903146的T等位基因与9天卧床休息诱导的胰岛素抵抗的胰岛素分泌减少补偿相关

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摘要

The aim of this study was to determine whether the type 2 diabetes-associated T-allele of transcription factor 7-like 2 (TCF7L2) rs7903146 associates with impaired insulin secretion to compensate for insulin resistance induced by bed rest.
机译:这项研究的目的是确定转录因子7样2(TCF7L2)rs7903146的2型糖尿病相关性T等位基因是否与受损的胰岛素分泌相关,以补偿卧床休息引起的胰岛素抵抗。

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  • 来源
    《Diabetes》 |2010年第4期|p.836-843|共8页
  • 作者单位

    Amra C. Alibegovic,1 Mette P. Sonne,2,3 Lise Hejbjerre,2,3 Torben Hansen,4,5 Oluf Pedersen,4,6 Gerrit van Hall,3,7 Jens J. Hoist,3 Bente Stallknecht,2,3 Flemming Delà,2,3 and Allan Vaag1From the 'Steno Diabetes Centre, Gentofte, Denmark, die 2Center for Healthy Ageing, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, the :tDepartment of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, the 4Hagedorn Research Institute, Gentofte, Denmark, Institute of Biomedical Science, University of Copenhagen, Copenhagen, Denmark, the r'Faculty of Health Science, University of Southern Denmark, Aarhus, Denmark, the "Faculty of Health Science, University of Aarhus, Aarhus, Denmark, and die 7Metabolic Mass-Spectrometry Facility, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.Corresponding author Amra Ciric Alibegovic, aagv@steno.dk.Received 21 June 2009 and accepted 17 January 2010. Published ahead of print at httpy/diabetes.diabete^ioumals.org on 27 January 2010. DOI: 10.2337/ db09-0918.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/Ucenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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