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Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment

机译:链脲佐菌素诱导的糖尿病大鼠背根神经节线粒体呼吸链功能障碍及胰岛素治疗

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摘要

Impairments in mitochondrial physiology may play a role in diabetic sensory neuropathy. We tested the hypothesis that mitochondrial dysfunction in sensory neurons is due to abnormal mitochondrial respiratory function.
机译:线粒体生理障碍可能在糖尿病感觉神经病中起作用。我们检验了感觉神经元中的线粒体功能障碍是由于线粒体呼吸功能异常引起的这一假设。

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  • 来源
    《Diabetes》 |2010年第4期|p.1082-1091|共10页
  • 作者单位

    Subir K. Roy Chowdhury,1 Elena Zherebitskaya,1 Darrell R. Smith,1'2 Eli Akude,1,2 Sharmila Chattopadhyay,3 Corinne G. Jolivalt,3 Nigel A. Calcutt,3 and Paul Fernyhough1,2From the 1 Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada, the 2 Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada, and the 3 Department of Pathology, University of California San Diego. La Jolla, California.Corresponding author: Subir K. Roy Chowdhury, skr_chowdhury@yahoo.ca.Received 1 September 2009 and accepted 9 January 2010. Published ahead of print at http://diabetes.diabetesjournals.org on 26 January 2010. DOI: 10.2337/db09-1299.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement'' in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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