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Involvement of MicroRNAs in the Cytotoxic Effects Exerted by Proinflammatory Cytokines on Pancreatic [beta]-Cells

机译：MicroRNA参与促炎细胞因子对胰腺β-细胞产生的细胞毒性作用

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摘要

Pancreatic beta-cells exposed to proinflammatory cytokines display alterations in gene expression resulting in defective insulin secretion and apoptosis. MicroRNAs are small noncoding RNAs emerging as key regulators of gene expression. Here, we evaluated the contribution of microRNAs to cytokine-mediated beta-cell cytotoxicity.
机译：暴露于促炎性细胞因子的胰腺β细胞显示基因表达的改变，导致胰岛素分泌和细胞凋亡缺陷。 MicroRNA是小的非编码RNA，正在成为基因表达的关键调节因子。在这里，我们评估了microRNA对细胞因子介导的β细胞细胞毒性的贡献。

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  • 来源
    《Diabetes》 |2010年第4期|p.978-986|共9页
  • 作者

    Elodie Roggli Aurore Britan Sonia Gattesco Nathalie Lin-Marq Amar Abderrahmani Paolo Meda Romano Regazzi;

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    Elodie Roggli,1 Aurore Britan,2 Sonia Gattesco,1 Nathalie Lin-Marq,3 Amar Abderranrnani,1,4 Paolo Meda,2 and Romano Regazzi1From the 'Department of Cell Biology and Morphology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland, the department of Cell Physiology and Metabolism, School of Medicine, University of Geneva, Geneva, Switzerland, the ''Department of Genetic Medicine and Development, Geneva Eurexpress, School of Medicine, LTniversity of Geneva, Geneva Switzerland, and the 4Service of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.Corresponding author: Romano Regazzi, romano.regazzi@unil.ch.Received 16 June 2009 and accepted 6 January 2010. Published ahead of print at http://diabetes.diabetesjoumals.org on 19 January 2010. DOI: 10.2337/db09-0881.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommoits.org/uceiises/by -nc-nd/3.0/ for details.The costs of publication of this article were defrayed in part by the payment of paye cfiaryes. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section i7M solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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