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Deficiency of Phosphoinositide 3-Kinase Enhancer Protects Mice From Diet-Induced Obesity and Insulin Resistance

机译:磷酸肌醇3-激酶增强剂的缺乏可保护小鼠免受饮食诱导的肥胖和胰岛素抵抗

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摘要

Phosphoinositide 3-kinase enhancer A (PIKE-A) is a proto-oncogene that promotes tumor growth and transformation by enhancing Akt activity. However, the physiological functions of PIKE-A in peripheral tissues are unknown. Here, we describe the effect of PIKE deletion in mice and explore the role of PIKE-A in obesity development.
机译:磷酸肌醇3-激酶增强剂A(PIKE-A)是一种原癌基因,可通过增强Akt活性来促进肿瘤生长和转化。然而,未知PIKE-A在外周组织中的生理功能。在这里,我们描述了PIKE删除在小鼠中的作用,并探讨了PIKE-A在肥胖症发展中的作用。

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  • 来源
    《Diabetes》 |2010年第4期|p.883-893|共11页
  • 作者单位

    Chi Bun Chan,1 Xia Liu,1 Dae Young Jung,2,3 John Y. Jun,2 Hongbo R. Luo,4 Jason K. Kim,2'3 and Keqiang Ye1From the 'Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, the department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, the aProgram in Molecular Medicine and Department of Medicine, Division of Endocrinology, Metabolism and Diabetes, University of Massachusetts Medical School, Worcester, Massachusetts, and the 'Department of Pathology and Lab Medicine. Harvard Medical School and Children's Hospital Boston, Boston, Massachusetts.Corresponding author: Keqiang Ye, kye@emory.edu.Received 21 September 2009 and accepted 21 December 2009. Published ahead of print at http://diabetes.diabetesjournals.org on 12 January 2010. DOI: 10.2337/db09-1404.© 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details.The costs of publication of Oris article were defrayed in part by the payment of paye cftaryes, This article must therefore, be hereby marked "advertisement" in accordance with 18 V.S.C. Section 1734 solely to indicate this fact.,;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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  • 正文语种 eng
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