Identification and Functional Characterization of the Peroxisomal Proliferator Response Element in Rat GLUT2 Promoter

摘要

We identified the peroxisomal proliferator response element (PPRE0 in the +68/+89 region of the rat GLUT2 gene. To identify whether the putative PPRE in the GLUT2 gene (GLUT2-PPRE) is functional, GLUT2 pro- Moter-luciferase reporter constructs were trnasfected Into CV-1 cells. Promoter activities were increased by Coexpresison of peroxisomal proliferator-activated Receptor (PPAR)-γ, retinoid X receptor (RXR)-α, and Treatment of their ligands; troglitazone and 9-cis Retinoic acid potentiated the transactivational effects.