NGAL for Preeclampsia: How Sure are We?

摘要

Pregnancy-related acute kidney injury (PR-AKI) is a life-threatening obstetric complication and accounts for 30–60% of all the complications. Among various risk factors for the development of AKI, preeclampsia plays a major role and it complicates almost 6–8% of pregnancies and is associated with maternal morbidity and mortality.1 The diagnostic criteria for defining AKI in pregnancy are also not validated as the existing criteria like Risk, Injury, Failure, Loss, End-stage (RIFLE) and Acute Kidney Injury Network (AKIN) have not been used for pregnant patients. The normal physiological changes in pregnancy and increase in glomerular filtration rate reduce creatinine in pregnancy,2 hence making the validity of these scores doubtful.