Understanding the roles of N 6-methyladenosine writers, readers and erasers in breast cancer

摘要

Breast cancer is believed to be driven by epigenetic regulation of genes implicated in cell proliferation, survival, and differentiation. Recently, aberrant N ~(6)-methyladenosine (m ~(6)A) decorations turned up as crucial epigenetic regulator for malignant breast cancer, which may serve as new targets for breast cancer treatment. Here we briefly outline the functions of m ~(6)A and its regulatory proteins, including m ~(6)A “writers,” “readers,” and “erasers” on RNA life fate, recapitulate the latest breakthroughs in understanding m ~(6)A modification and its regulatory proteins, and the underlying molecular mechanisms that contribute to the carcinogenesis and the progression of breast cancer, so as to provide potential epigenetic targets for diagnosis, treatment and prognosis in breast cancer.