Petroselinum crispumvar. neapolitanumDanert (Apiaceae) (PC), popularly known as parsley, is an herb native to the Mediterranean region widely cultivated around the world for culinary and ethnomedicinal purposes. The herb is traditionally used in various parts of the world to treat arterial hypertension, hemorrhoid, nose bleeding, hyperlipidemia, and pain, among other indications. The aim of this study was to evaluate the antithrombotic activity of an aqueous extract PC in rats. Aerial parts of a flat-leaf variety of parsley were extracted by decoction.In?vivothrombosis in rat models as well asex?vivoassays were used in the evaluation of PC antithrombotic effects. Intravenous administration of PC (25?mg/kg.b.w), 5?min before thrombosis induction, reduced the venous thrombus formation by 98.2%, while oral administration (125?mg/kg.b.w) impaired it by 76.2%. In the arterial thrombosis model, the oral administration of PC at 15 or 25?mg/kg.b.w, 60?min before thrombosis induction, increased the carotid artery occlusion time by 150% (37.0?±?6.44?min) and 240% (more than 60?min), respectively. A HPLC-DAD-MS/MS profile of PC extract used in this study was provided. Apiin showed to be the most abundant phenolic compound in the extract. It also revealed the presence of many coumaric acid derivatives. Our results indicate that PC is a potential candidate for the development of a phytotherapeutic drug in the treatment of thromboembolic diseases and provide a detailed chemical profile useful for controlling PC extract production in view of phytotherapy.
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