Background: To determine the optimum conditions for diagnosis of nasopharyngeal carcinoma, we established VX2 rabbit model to delineate gross target volume (GTV) in different imaging methods. Methods: The orthotopic nasopharyngeal carcinoma (NPC) was established in sixteen New Zealand rabbits. After 7-days inoculation, the rabbits were examined by CT scanning and then sacrificed for pathological examination. To achieve the best delineation, different GTVs of CT, MRI, 18 F-FDG PET/CT, and 18 F-FLT PET/CT images were correlated with pathological GTV (GTVp). Results: We found 45% and 60% of the maximum standardized uptake value (SUV max ) as the optimal SUV threshold for the target volume of NPC in 18 F-FDG PET/CT and 18 F-FLT PET/CT images, respectively (GTV FDG45% and GTV FLT60% ). Moreover, the GTV MRI and GTV CT were significantly higher than the GTVp (P ≤ 0.05), while the GTV FDG45% and especially GTV FLT60% were similar to the GTVp (R = 0.892 and R = 0.902, respectively; P ≤ 0.001). Conclusions: Notably, the results suggested that 18 F-FLT PET/CT could reflect the tumor boundaries more accurately than 18 F-FDG PET/CT, MRI and CT, which makes 18 F-FLT PET-CT more advantageous for the clinical delineation of the target volume in NPC.? The author(s).
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机译：背景：为了确定诊断鼻咽癌的最佳条件，我们建立了VX2兔模型以在不同的成像方法中描绘总目标量（GTV）。方法：原位鼻咽癌（NPC）成立于十六位新西兰兔。在7天接种后，通过CT扫描检查兔子，然后为病理检查处死。为了达到最佳描绘，CT，MRI，18 F-FDG PET / CT和18 F-FLT PET / CT图像的不同GTV与病理GTV（GTVP）相关。结果：我们发现了45％和60％的最大标准化摄取值（SUV MAX）作为18 F-FDG PET / CT和18 F-FLT / CT图像中NPC的目标体积的最佳SUV阈值（ GTV FDG45％和GTV FLT60％）。此外，GTV MRI和GTV CT显着高于GTVP（P≤0.05），而GTV FDG45％且尤其是GTV FLT60％的GTVP（r = 0.892和r = 0.902）类似;p≤0.001） 。结论：特别是，结果表明，18个F-FLT PET / CT可以比18 F-FDG PET / CT，MRI和CT更精确地反映肿瘤界限，这使得18 F-FLT PET-CT对临床描绘更有利NPC中的目标体积。作者。
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