Closing mucosal defects after duodenal endoscopic sub- mucosal dissection (ESD) decreases the risk of postopera- tive adverse events. 1 Although various methods for closure have been proposed, 2,3 a single reliable and safe method has not yet been established. Herein, we propose the underwater reopenable clip closure (U-REC), a novel technique for closing mucosal defects after duodenal ESD.
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