Chronic joint pain due to loss of cartilage function, degradation of subchondral bone, and related conditions are common plights of an arthritis patient.Antioxidant compounds could solve the problems in arthritic condition. The objective of this study was to evaluate the anti-arthritic activity of D-carvone againstcomplete Freund’s adjuvant (CFA)-induced arthritis in rats. D-carvone was orally administered for 25 days at the doses of 30 and 60 mg/kg against CFA-induced arthriticrats. Changes in body weight, paw swelling, organ index, hematological parameters,oxidative stress markers, inflammatory cytokines, and histopathology were recorded.Oral treatment of D-carvone significantly improved the body weight, reduced thepaw swelling, edema formation, and organ index in arthritic rats. The levels of whiteblood cells were reduced, red blood cells and hemoglobin levels were improved inD-carvone treated arthritic rats. Lipid peroxidation levels were lowered whereas enzymatic and non-enzymatic antioxidants were significantly elevated by D-carvoneadministration against arthritic rats. D-carvone significantly modulated inflammatorycytokine levels and improved the ankle joint pathology against CFA-induced arthriticinflammation. In conclusion, D-carvone proved significant anti-arthritic activityagainst CFA-induced arthritis in rats.
展开▼
