BACKGROUND:long noncoding RNAs (lncRNAs) have attracted attention recently. However, many inconsistencies frequently appeared for the early diagnosis of digestive tract cancers (DTCs). We performed this meta-analysis to describe the diagnostic performance of lncRNAs in the discrimination of DTCs.METHODS:data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. Their quality was evaluated using the revised Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Such parameters as sensitivity and specificity were included for pooled analyses. The STATA 12.0 and Meta-Disc 1.4 software packages were used to perform the statistical analysis.RESULTS:sixty-nine papers were included in this meta-analysis. The pooled analysis of DTCs showed that lncRNAs had a sensitivity of 0.78 and a specificity of 0.80. The area under the summary ROC curve (AUC) was 0.86. For gastric cancer (GC), the pooled sensitivity and specificity were 0.77 (95 % CI: 0.72-0.81) and 0.75 (95 % CI: 0.71-0.79), respectively, and the AUC was 0.83. For colorectal cancer (CRC), these three parameters were 0.82 (95 % CI: 0.76-0.86), 0.84 (95 % CI: 0.79-0.88), and 0.90, respectively. For esophageal cancer (EC) sensitivity was 0.74 (95 % CI: 0.67-0.80) and specificity reached 0.86 (95 % CI: 0.72-0.93), with an AUC of 0.82.CONCLUSIONS:LncRNAs show potential diagnostic value for discrimination between DTCs.
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机译：背景：长时间的非划分RNA（LNCRNA）最近引起了关注。然而，许多不一致似乎对消化道癌症的早期诊断（DTC）进行了早期诊断。我们进行了该META分析，以描述LNCRNA在DTCS中的判断中的诊断性能。方法：数据来自PubMed，Semast，Embase和Cochrane图书馆。使用对诊断准确性研究-2（Quadas-2）的修订质量评估来评估其质量。包括融合性和特异性的这种参数被包括用于汇集分析。 STATA 12.0和META-DISC 1.4软件包用于执行统计分析。结果：在该荟萃分析中包括六十九份纸张。 DTC的汇总分析表明，LNCRNA的灵敏度为0.78，特异性为0.80。摘要ROC曲线（AUC）下的该区域为0.86。对于胃癌（GC），汇集敏感性和特异性分别为0.77（95％CI：0.72-0.81）和0.75（95％CI：0.71-0.79），AUC为0.83。对于结直肠癌（CRC），这三个参数分别为0.82（95％CI：0.76-0.86），0.84（95％CI：0.79-0.88）和0.90。对于食管癌（EC）敏感性为0.74（95％CI：0.67-0.80），特异性达到0.86（95％CI：0.72-0.93），均为0.82。结论：LNCRNA显示DTC之间歧视的潜在诊断价值。
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