Binary titanium–niobium (Ti–Nb) alloys have recently been attracted due to low Young’s moduli and non-toxic properties. This study explores the influence of low Nb content (0–25?wt%) on the comprehensive parameters of tensile stress–strain relationships (ultimate strength (σUTS), yield strength (σ0.2) and elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) and scanning electron microscopy (SEM)), corrosion resistance (in artificial saliva and lactic acid) and biological properties (cytotoxicity and alkaline phosphatase activity of MC3T3-E1 pre-osteoblasts) of Ti–xNb alloys (x?=?5, 10, 15, 20 and 25?wt%), with using commercially pure grade 2 titanium (cp-Ti) as control. XRD results shown that all the Ti–xNb alloys comprised α?+?β Ti alloy phases, such that the β phase increased correspondingly with the increased amount of Nb in the alloy, as well as the reduction of E (69–87?GPa). Except Ti–5Nb, all other Ti–xNb alloys showed a significantly higher hardness, increased σUTS and σ0.2, and decreased WCA compared with cp-Ti. No corrosion was detected on Ti–xNb alloys and cp-Ti in artificial saliva and lactic acid solutions. The cytotoxicity of Ti–xNb alloys was comparable to that of cp-Ti in MC3T3-E1 pre-osteoblasts without interference from differentiation behaviour, but the proliferation rate of the Ti–5Nb alloy was lower than other groups. In overall, binary Ti–(10–25?wt%)Nb alloys are promising candidate for orthopaedic and dental implants due to their improved mechanical properties and comparable biological performance, while Ti–5Nb should be used with caution.
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