Scar formation seriously affects the repair of damaged skin especially in adults and the excessive inflammation has been considered as the reason. The self-assembled peptide-hydrogels are ideal biomaterials for skin wound healing due to their similar nanostructure to natural extracellular matrix, hydration environment and serving as drug delivery systems. In our study, resveratrol, a polyphenol compound with anti-inflammatory effect, is loaded into peptide-hydrogel (Fmoc-FFGGRGD) to form a wound dressing (Pep/RES). Resveratrol is slowly released from the hydrogel in situ, and the release amount is controlled by the loading amount. The in vitro cell experiments demonstrate that the Pep/RES has no cytotoxicity and can inhibit the production of pro-inflammatory cytokines of macrophages. The Pep/RES hydrogels are used as wound dressings in rat skin damage model. The results suggest that the Pep/RES dressing can accelerate wound healing rate, exhibit well-organized collagen deposition, reduce inflammation and eventually prevent scar formation. The Pep/RES hydrogels supply a potential product to develop new skin wound dressings for the therapy of skin damage.
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机译:疤痕形成严重影响受损皮肤的修复,特别是在成人中,过度的炎症被认为是原因。自组装的肽 - 水凝胶是用于皮肤伤口愈合的理想生物材料,由于它们与天然细胞外基质,水合环境和作为药物递送系统的类似纳米结构。在我们的研究中,白藜芦醇是一种具有抗炎作用的多酚化合物,被装入肽 - 水凝胶(FMOC-FFGGRGD)中以形成伤口敷料(PEP / RES)。将白藜芦醇从水凝胶中慢慢释放出原位,并且释放量由装载量控制。体外细胞实验表明,PEP / RE无细胞毒性,可以抑制巨噬细胞的促炎细胞因子的产生。 PEP / RES水凝胶用作大鼠皮肤损伤模型中的伤口敷料。结果表明,PEP / RE敷料可以加速伤口愈合率,表现出良好组织的胶原沉积,减少炎症,最终防止疤痕形成。 PEP / RES水凝胶提供潜在的产品,用于开发新的皮肤伤口敷料,用于治疗皮肤损伤。
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