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MicroRNAs and autism spectrum disorder: small tools for a complex disorder

机译:MicroRNA和自闭症谱系:复杂疾病的小工具

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The autism spectrum disorder (ASD) includes a complex group of neural development disorders that arecharacterized by deficiencies in social interaction, communication, and motor skills of individuals. ASD has animpact on public health, so it would be very useful to have biomarkers that allow early identification of thedisorder. In this sense, microRNAs (miRNAs), which are regulators of a wide variety of cellular functionsand whose alterations in their expression have been observed in individuals with ASD, are beginning to beconsidered as potential targets for the development of diagnostic and therapeutic strategies for thesedisorders. This review focuses on some studies about the participation of miRNAs in ASD in animal models,as well as in humans, and makes an approach to their possible use as biomarkers.
机译:自闭症谱系障碍(ASD)包括一组复杂的神经发育障碍,其通过社会互动,沟通和个人的运动技能的缺陷而引人注目。 ASD在公共健康方面拥有动画,因此拥有允许早期识别分数的生物标志物是非常有用的。从这个意义上讲,MicroRNA(miRNA),其是各种细胞功能的调节因子,其在亚本大学的个人中观察到其表达的改变,开始被视为发展诊断和治疗策略的潜在目标。本综述重点是一些关于MiRNA参与ASD在动物模型中的研究,以及在人类中,并使他们可能用作生物标志物的方法。

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