Introduction and Objectives: Peyronie’s disease is a fibrotic, multifocalstructural degeneration of the penile tunica albuginea, and is one of themost common causes of pathological penile bending acquired chordee.Fibrosis is a prominent feature in PyD and is characterized by a process ofreplacement of normal tissue by mesenchymal cells and the extracellularmatrix produced by these cells. The excessive deposition of collagen givesrise to a plaque, which is initially fibrotic, and then, over time, can becomecalcific. The aim of this study was to evaluate any relationship between theantinuclear antibody and PyD.Methods: We recruited 100 consecutive patients diagnosed with PyD byclinical and ultrasound examinations (group A). Another 30 healthy individualswho had no curvature of the penis, congenital or acquired, andwho offered no history of trauma, served as the control group (group B).Basic laboratory investigations were obtained. Antinuclear antibody titres(ANA) together with serum total testosterone (TT), free testosterone (FT),and sex hormone binding globulin (SHBG) were all obtained.Results: Demographic parameters were comparable in both groups. SerumTT and FT were significantly lower in group A than group B. No similarfindings were obtained regarding SHBG. The normal titer of ANA is 1:40 orless. Higher titers are indicative of an autoimmune disease. ANA antibodymay positive in 5% of individuals. Only 8 (8%) and 3 (10%) patients hadpositive ANA positive titres in groups A and B, respectively. All 11 patientsexpressed a speckled pattern in their positive ANA titres.Conclusions: We have not found any significant association of the ANAtitres in patients with PyD. Low testosterone blood levels may be associatedwith PyD.
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