Background: Parkinson’s disease (PD) is the second common neurodegenerative disorder afflicting a large number of elder populations. Itis mainly considered a movement disorder; however, the non-motor symptoms have a significant impact on the patients’ quality of life.This study aimed to evaluate the possible effect of mindfulness-based stress reduction training (MBSR) on the quality of life of patientswith PD.Materials and Methods: This study was conducted at the outpatient neurology clinic of Imam Reza and Razi University-Hospital-Tabriz,Iran. Participants were 40 patients aged 67.95±6.8 years (56-80) with a definite diagnosis of PD who were receiving dopaminergic drugsfor at least one year. Participants were randomly categorized into experiment and control groups with 20 patients in each. The experimentincluded 8-week MBSR training each for 2h with a 15-minute break between the first and second hours. The assessments includedpatients’ quality of life using the 39-Item Parkinson's disease questionnaire (PDQ-39) at baseline and after the experiment. The resultswere compared between two study groups and within each group using t-test analysis.Results: The assessment revealed a lower mean score in all PDQ-39 items in the experiment group compared to control group; however,the difference was only significant for social support (34.13±9.7 vs 26.19±7.7 for control and experiment group, respectively. P=0.007).The mean PDSI score of patients in the experiment group was 31.88±6.5 after one month compared to the baseline score of 33.93±6.2(p0.001). Overall PDSI decreased modestly in the experiment group by 5.12% after the experiment.Conclusion: In our study, mindfulness training improved the overall quality of life in PD patients. However, long-term follow up on alarge-scale population is required to evaluate the impact of mindfulness-based stress reduction on each item.
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