Dengue fever remains the most common mosquito-borne viral disease in humans.The dengue virus belongs to the Flavivirus genus of the family Flaviviridae, andits members include the four antigenically related serotypes of dengue virus. It istransmitted to humans by the bite of an infected female Aedes aegypti mosquito.Recovery from infection with one serotype provides lifelong immunity against thatserotype but confers only transient and partial immunity against subsequent infectionby other serotypes. (Gubler 1998) Sequential infections with other serotypes mayincrease the risk of more serious systemic disease, such as dengue hemorrhagic feveror dengue shock syndrome, which are life-threatening. (Gubler 1998),(Gibbons andVaughn 2002)In recent years there has been a signifi cant increase in literature on dengue-associatedeye disease.(Chan et al. 2006),(Ng and Teoh 2015),(Su et al. 2007) A spectrum ofclinical manifestations has been described in association with dengue fever andindicates several diff erent pathophysiological mechanisms responsible for theseclinical manifestations.(Su et al. 2007),(Bacsal et al. 2007),(Lim et al. 2004) In thisreview, we focus on growing literature on dengue-associated eye disease and aim toprovide a comprehensive review as well as practical clues for how to recognize andtreat some of these common ocular manifestations.
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