Immunotherapy for Multiple Organ Failure in Children

摘要

Multiple organ failure syndrome is determined by the presence of dysfunction of two or more systems of an organism. A total of 60 children aged 3 months to 4 years with diagnosed multiple organ failure were under observation in the intensive care unit and in the paediatric department of the RRCEM. The reason for the development of multiple organ failure syndrome are inflammatory diseases of the lung - 41 (68,3%), combined and associated injuries – 7 (11,7%), sepsis - 12 (20%). In children with polyorgan failure, CD3+, CD4+ and CD16+- lymphocyte count were reduced, CD25+, CD38+ and CD95+- lymphocytes were elevated, B-lymphocyte counts were elevated, and IgA, IgG and IgM immunoglobulin counts were below normal. Level of IL-1 in patients was significantly elevated (p<0,001). For all 60 children with multiple organ failure after the examination were provided immunocorrection with the immunological medication Octagm 30-50 mg/kg 2 times, once a week. Inclusion of Octagam in the complex therapy of children with multiple organ failure led to the increase of initially decreased indexes of the immune cellular link, stabilizated of humoral immunity, shortening the terms of antibacterial therapy, shortening the terms of hospitalization.