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首页> 外文期刊>IBRO Reports >Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats
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Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats

机译:大鼠脑内静脉内出血组合模型中溶均溶胶的神经保护潜力

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Intracerebral hemorrhage (ICH) may be caused by trauma, aneurysm and arteriovenous malformation, as can any bleeding within the intracranial vault, including brain parenchyma and adjacent meningeal spaces (aneurism and atreovenous malformation). ICH is the cerebral stroke with the least treatable form. Over time, intraventricular hemorrhage (IVH) is associated with ICH, which contributes to hydrocephalus, and the major cause of most hemorrhagic death (Due to the cerebral hemorrhage and post hemorrhagic surgeries). Most patients suffer from memory impairment, grip strength, posture, and cognitive dysfunctions attributable to cerebral hemorrhage or post-brain hemorrhagic surgery. Nevertheless, a combined model of ICH based IVH is not present pre-clinically. Autologous blood (ALB) injection (20 μl/5 min) in the rat brain triggers hemorrhage, such as factors that further interfere with the normal functioning of neuroinflammatory cytokines, oxidative stress, and neurotransmitter dysfunction, such as CoQ10 insufficiency and dysregulation of mitochondrial ETC-complexes. For the prevention of post-brain hemorrhagic behavioral and neurochemical dysfunctions, there is no specific drug treatment available, only available therapy used to provide symptomatic relief. The current study reveals that long-term administration of Solanesol (SNL) 40 and 60 mg/kg alone and in combination with available drug therapy Donepezil (DNP) 3 mg/kg, Memantine (MEM) 20 mg/kg, Celecoxib (CLB) 20 mg/kg, Pregabalin (PGB) 30 mg/kg, may provide the neuroprotective effect by improving behavioral and neurochemical deficits, and gross pathological changes in ALB induced combined experimental model of ICH-IVH in post brain hemorrhagic conditions in rats. Thus, SNL can be a potential therapeutic approach to improve neuronal mitochondrial dysfunction associated with post brain hemorrhagic behavioral and neurochemical alterations.
机译:颅内出血(ICH)可能是由创伤,动脉瘤和动静脉畸形引起的,因为颅内穹窿内的任何出血,包括脑实质和相邻的脑膜空间(动力学和畸形)。 ich是具有最低可治疗形式的脑卒中。随着时间的推移,脑室内出血(IVH)与ICH有关,这有助于脑积水,以及大多数出血性死亡的主要原因(由于脑出血和出血后手术后)。大多数患者患有记忆障碍,握持强度,姿势和认知功能障碍,归因于脑出血或后脑后出血手术。然而,基于IVH的组合模型不在临床上存在。大鼠脑中的自体血液(ALB)注射(20μl/ 5min)触发出血,例如进一步干扰神经炎细胞因子,氧化应激和神经递质功能障碍的正常功能的因素,例如CoQ10不足和线粒体的失调等 - 复杂。为了预防后脑后出血行为和神经化学功能障碍,没有可用的特定药物治疗,只有可用的疗法提供症状浮雕。目前的研究表明,单独的单独药物(SN1)40和60mg / kg的长期施用,并与可用的药物疗法组合多哌齐(DNP)3mg / kg,Memantine(Mem)20mg / kg,Celecoxib(CLB) 20毫克/千克,普瑞巴林(PGB)30毫克/千克,可通过改善行为和神经化学缺陷来提供神经保护作用,以及大鼠后脑出血条件的ACH-IVH中的ALB诱导组合实验模型的总病理变化。因此,SNL可以是改善与后脑出血行为和神经化学改变相关的神经元线粒体功能障碍的潜在治疗方法。

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