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首页> 外文期刊>Advanced Science >Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)
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Biocompatibility of Nanoparticles: Hematological Effects of Gold Nanorods on Erythrocytes: Hemolysis and Hemoglobin Conformational and Functional Changes (Adv. Sci. 12/2017)

机译:纳米粒子的生物相容性:金纳米棒对红细胞的血液效应:溶血和血红蛋白构象和功能变化(江舞。12/2017)

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摘要

Abstract In article 1700296 , Qunfang Zhou and co-workers report the hemocompatibility of gold nanorods (GNRs). In contrast to negatively charged GNRs, positively charged GNRs (C-GNRs) induce instant hemolysis. After cellular encapsulation, the GNRs are found to bind with hemoglobin and to induce conformational and functional changes in the protein. This demonstrates that surface modification holds great promise as an approach to improve the biocompatibility of GNRs for clinical use.
机译:摘要在第1700296章中,昆车周和同事报告了金纳米棒(GNRS)的血液相位性。与带负电的GNR相比,带正电荷的GNR(C-GNR)诱导即时溶血。在细胞包封后,发现GNRS与血红蛋白结合并诱导蛋白质的构象和功能变化。这表明表面改性具有巨大的希望作为提高GNRS临床使用的生物相容性的方法。

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