Comparison of Cross Sectional Areas of Median Nerve in Type 2 Diabetic Patients with Peripheral Neuropathy with Healthy Adult Subjects Measured by 2 D-B Mode High Resolution Ultrasonography

摘要

Background: Patients with diabetic peripheral neuropathy (DPN) have distal, symmetrical form of the disordercharacterized by numbness, burning feet, pins-and-needles sensations and lightning pain. This study wasdesigned to find out the difference between 2 Dimentional (D)-Brightness (B) mode high resolutionultrasonographically measured cross sectional areas of median nerve in type 2 diabetic patients with peripheralneuropathy and those of non-diabetic healthy adult subjects.Methods: This case-control study was done on 180 subjects aged 27-67 years in the department of Radiologyand Imaging, BIRDEM from January 2012 to December 2013. Out of them 90 diabetic patients with peripheralneuropathy diagnosed electrophysiologically by nerve conduction study (NCS) were considered study groupand age, sex and weight compatible 90 healthy subjects were considered as control group.Measurement of cross sectional areas of median nerve was performed first by the investigator himselfpurposefully, consecutively and subsequently confirmed by a radiologist in the department of Radiology andImaging, BIRDEM, who did not know the subjects’ condition to eliminate bias. The major axis, minor axis andthe cross sectional areas (CSA) of the median nerve were measured at the carpal tunnel.Results: In this study, the mean cross sectional areas (mm2) of median nerve healthy subjects was 7.78±1.00mm2 and in diabetic patients with peripheral neuropathy was 13.67±2.97 mm2. The difference mean CSA ofmedian nerve of diabetic subjects with peripheral neuropathy and control subjects were statistically significant(p<0.05) in unpaired ‘t’ test.Conclusion: This study showed that there is a significant difference between the cross sectional areas of mediannerve in diabetic subjects with peripheral neuropathy and healthy adult subjects. The mean cross sectional areasof median nerve were increased in diabetic patients with peripheral neuropathy compared to control group.