1. 1. The intravenous injection of anti-staphylococcus bacteriophage exerts a marked influence on the type of leukocytic response elicited by susceptible staphylococci, but has only a slight effect upon the type of response due to resistant organisms. This influence is characterized by the fact that a single injection of the bacteriophage together with susceptible organisms causes a decrease in the degree and time of appearance of the leukocytosis as compared with that due to susceptible organisms alone. Repeated injections of the bacteriophage increase the period of leukopenia and decrease the degree of leukocytosis as compared with that due to susceptible organisms alone. The bacteriophage does not alter the type of response due to resistant organisms in any way comparable to the effect of the bacteriophage on the type of leukocytic response due to susceptible organisms.2. 2. When leukocytes and organisms are brought into contact with the anti-staphylococcus bacteriophage in vitro , either in the presence or absence of serum, the degree of phagocytosis in the case of susceptible organisms is markedly increased, whereas in the case of resistant staphylococci the degree of phagocytosis is practically unaffected.3. 3. When anti-staphylococcus bacteriophage is injected intravenously there is an almost immediate increase in the phagocytic power of the leukocytes for susceptible organisms, whereas for resistant organisms the phagocytic power remains practically unaltered. The opsonic power is not altered appreciably in either case.
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